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Dendritic spines do not split during hippocampal LTP or maturation

Nature Neuroscience volume 5, pages 297298 (2002) | Download Citation

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Abstract

Synapse splitting is considered a viable mechanism for increasing synaptic coupling between neurons1,2,3,4,5. We investigated this issue by reconstructing dendrites, axons and synapses from hippocampus during long-term potentiation (LTP) and maturation. Long, mature axons passed between neighboring dendritic spine synapses, precluding their formation by splitting.

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Acknowledgements

Thanks to M. Feinberg, J. Cooney, A. Goddard, D. Castellano and E. Phillips for technical assistance. This work was supported by NIH grant NS33574 and by the Human Brain Project grant MH/DA57351 funded jointly by NIMH and NIDA.

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Author notes

    • Brenda Allwardt

    Present address: Finnegan, Henderson, L.L.P., 1300 I St., N.W., Washington, DC 20005

Affiliations

  1. Biology Department, Program in Neuroscience, Boston University, 5 Cummington St., Boston, Massachusetts 02215, USA

    • John C. Fiala
    •  & Kristen M. Harris

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Kristen M. Harris.

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DOI

https://doi.org/10.1038/nn830

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