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Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors

Nature Neuroscience volume 10, pages 1238–1240 (2007)Cite this article

Abstract

We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity. Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body.

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Figure 1: Glutamate receptor agonists and antagonists altered surface and total GluR2 receptors in cultured mouse auditory neurons.
Figure 2: Noise exposure reversibly decreased both cochlear surface AMPA receptor and auditory sensitivity in vivo.
Figure 3: Pharmacology of surface GluR2 removal.

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Acknowledgements

We appreciate the advice of A.S. Edge and F. Shi in developing the western blot analysis, that of B.P. Manning for the immunohistochemistry, that of C.E. Corrales in removing inner ears from mouse pups, and that of S. Heller for neuronal culture. We thank R.A. Eatock for critical comments on early versions of the manuscript. The work was supported by grants from the US National Institute on Deafness and Other Communication Disorders.

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Authors and Affiliations

  1. Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, 02114, Massachusetts, USA

    Zhiqiang Chen, Sharon G Kujawa & William F Sewell

  2. Department of Otolaryngology, Eaton Peabody Laboratory, 243 Charles Street, Boston, 02114, Massachusetts, USA

    Zhiqiang Chen, Sharon G Kujawa & William F Sewell

  3. Department of Audiology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, 02114, Massachusetts, USA

    Sharon G Kujawa

  4. Program in Neuroscience, Harvard Medical School, 220 Longwood Avenue, Boston, 02115, Massachusetts, USA

    William F Sewell

Authors
  1. Zhiqiang Chen
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  2. Sharon G Kujawa
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  3. William F Sewell
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Correspondence to William F Sewell.

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Chen, Z., Kujawa, S. & Sewell, W. Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors. Nat Neurosci 10, 1238–1240 (2007). https://doi.org/10.1038/nn1974

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