Abstract
We report that temporal spike sequences from hippocampal place neurons of rats on an elevated track recurred in reverse order at the end of a run, but in forward order in anticipation of the run, coinciding with sharp waves. Vector distances between the place fields were reflected in the temporal structure of these sequences. This bidirectional re-enactment of temporal sequences may contribute to the establishment of higher-order associations in episodic memory.
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References
Kahana, M.J. Mem. Cognit. 24, 103–109 (1996).
Drosopoulos, S., Windau, E., Wagner, U. & Born, J. PLoS ONE 2, e376 (2007).
Howard, M.W., Fotedar, M.S., Datey, A.V. & Hasselmo, M.E. Psychol. Rev. 112, 75–116 (2005).
Eichenbaum, H., Dudchenko, P., Wood, E., Shapiro, M. & Tanila, H. Neuron 23, 209–226 (1999).
Wilson, M.A. & McNaughton, B.L. Science 265, 676–679 (1994).
Buzsaki, G. Neuroscience 31, 551–570 (1989).
O'Keefe, J. & Dostrovsky, J. Brain Res. 34, 171–175 (1971).
O'Keefe, J. & Recce, M.L. Hippocampus 3, 317–330 (1993).
Skaggs, W.E., McNaughton, B.L., Wilson, M.A. & Barnes, C.A. Hippocampus 6, 149–172 (1996).
Foster, D.J. & Wilson, M.A. Nature 440, 680–683 (2006).
Mehta, M.R., Barnes, C.A. & McNaughton, B.L. Proc. Natl. Acad. Sci. USA 94, 8918–8921 (1997).
Jensen, O. & Lisman, J.E. J. Neurophysiol. 83, 2602–2609 (2000).
Skaggs, W.E. & McNaughton, B.L. Science 271, 1870–1873 (1996).
Lee, A.K. & Wilson, M.A. Neuron 36, 1183–1194 (2002).
Ferbinteanu, J. & Shapiro, M.L. Neuron 40, 1227–1239 (2003).
Acknowledgements
The authors would like to thank A. Amarasingham and S. Royer for excellent discussions, and S. Montgomery, A. Renart and D. Robbe for comments on the manuscript. This work was supported by the US National Institutes of Health (NS34994 and MH54671).
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K.D. and G.B. designed the experiments and wrote the manuscript. K.D. carried out the experiments and analyzed the data.
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Diba, K., Buzsáki, G. Forward and reverse hippocampal place-cell sequences during ripples. Nat Neurosci 10, 1241–1242 (2007). https://doi.org/10.1038/nn1961
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DOI: https://doi.org/10.1038/nn1961
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