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Forward and reverse hippocampal place-cell sequences during ripples

Nature Neuroscience volume 10, pages 1241–1242 (2007)Cite this article

Abstract

We report that temporal spike sequences from hippocampal place neurons of rats on an elevated track recurred in reverse order at the end of a run, but in forward order in anticipation of the run, coinciding with sharp waves. Vector distances between the place fields were reflected in the temporal structure of these sequences. This bidirectional re-enactment of temporal sequences may contribute to the establishment of higher-order associations in episodic memory.

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Figure 1: Forward and reverse pre- and replay of place-cell sequences.
Figure 2: Forward and reverse temporal sequences during ripples reflect distance representations of place cells on the track.

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Acknowledgements

The authors would like to thank A. Amarasingham and S. Royer for excellent discussions, and S. Montgomery, A. Renart and D. Robbe for comments on the manuscript. This work was supported by the US National Institutes of Health (NS34994 and MH54671).

Author information

Authors and Affiliations

  1. Center for Molecular and Behavioral Neurobiology, Rutgers University, 197 University Ave, Newark, 07102, New Jersey, USA

    Kamran Diba & György Buzsáki

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  1. Kamran Diba
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  2. György Buzsáki
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Contributions

K.D. and G.B. designed the experiments and wrote the manuscript. K.D. carried out the experiments and analyzed the data.

Corresponding authors

Correspondence to Kamran Diba or György Buzsáki.

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Supplementary Figures 1–12, Methods and Results (PDF 3008 kb)

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Diba, K., Buzsáki, G. Forward and reverse hippocampal place-cell sequences during ripples. Nat Neurosci 10, 1241–1242 (2007). https://doi.org/10.1038/nn1961

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