Abstract
Different streams of sensory information are transmitted to the cortex where they are merged into a percept in a process often termed 'binding.' Using recordings from triplets of rat cortical layer 2/3 and layer 5 pyramidal neurons, we show that specific subnetworks within layer 5 receive input from different layer 2/3 subnetworks. This cortical microarchitecture may represent a mechanism that enables the main output of the cortex (layer 5) to bind different features of a sensory stimulus.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice
Nature Communications Open Access 25 March 2023
-
Graphene-electrode array for brain map remodeling of the cortical surface
NPG Asia Materials Open Access 01 October 2021
-
A gradual depth-dependent change in connectivity features of supragranular pyramidal cells in rat barrel cortex
Brain Structure and Function Open Access 26 February 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Hubel, D.H. & Wiesel, T.N. J. Physiol. (Lond.) 160, 106–154 (1962).
Mountcastle, V.B. J. Neurophysiol. 20, 408–434 (1957).
Song, S., Sjostrom, P.J., Reigl, M., Nelson, S. & Chklovskii, D.B. PLoS Biol. [online] 3, e68 (2005) (doi:10.1371/journal.pbio.0030068).
Wang, Y. et al. Nat. Neurosci. 9, 534–542 (2006).
Yoshimura, Y., Dantzker, J.L. & Callaway, E.M. Nature 433, 868–873 (2005).
Shepherd, G.M. & Svoboda, K. J. Neurosci. 25, 5670–5679 (2005).
Bosking, W.H., Zhang, Y., Schofield, B. & Fitzpatrick, D. J. Neurosci. 17, 2112–2127 (1997).
Marino, J. et al. Nat. Neurosci. 8, 194–201 (2005).
Sincich, L.C. & Blasdel, G.G. J. Neurosci. 21, 4416–4426 (2001).
Weliky, M., Kandler, K., Fitzpatrick, D. & Katz, L.C. Neuron 15, 541–552 (1995).
Berman, N., Payne, B.R., Labar, D.R. & Murphy, E.H. J. Neurophysiol. 48, 1362–1377 (1982).
Martinez, L.M. et al. Nat. Neurosci. 8, 372–379 (2005).
Williams, S.R. & Stuart, G.J. Science 295, 1907–1910 (2002).
Kampa, B.M., Letzkus, J.J. & Stuart, G.J. J. Physiol. (Lond.) 574, 283–290 (2006).
Letzkus, J.J., Kampa, B.M. & Stuart, G.J. J. Neurosci. 26, 10420–10429 (2006).
Acknowledgements
We thank C. Stricker and J. Bekkers for help with the analysis and F. Helmchen, C. Gee and W. Schweer for comments on the manuscript.
Author information
Authors and Affiliations
Contributions
B.M.K. designed the experiments and did the calculations; B.M.K. and J.J.L. performed the experiments and data analysis; B.M.K., J.J.L. and G.J.S. jointly discussed the results and wrote the manuscript.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Figure 1
Integrative feed-forward networks in the neocortex. (PDF 41 kb)
Rights and permissions
About this article
Cite this article
Kampa, B., Letzkus, J. & Stuart, G. Cortical feed-forward networks for binding different streams of sensory information. Nat Neurosci 9, 1472–1473 (2006). https://doi.org/10.1038/nn1798
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn1798
This article is cited by
-
Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice
Nature Communications (2023)
-
Graphene-electrode array for brain map remodeling of the cortical surface
NPG Asia Materials (2021)
-
Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex
Neuroscience Bulletin (2021)
-
Anatomy and function of an excitatory network in the visual cortex
Nature (2016)
-
Multilaminar networks of cortical neurons integrate common inputs from sensory thalamus
Nature Neuroscience (2016)
