We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level–dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30–44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.
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We thank S. Hulland, S. Brown and J. James for technical assistance. This work was supported by grants from the National Institute of Mental Health (MH072837 to A.R.H., and MH067602 and MH64625 to C.C.M.) and from the National Alliance for Research on Schizophrenia and Depression (Young Investigator Award to A.R.H.).
The authors declare no competing financial interests.
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Fisher, P., Meltzer, C., Ziolko, S. et al. Capacity for 5-HT1A–mediated autoregulation predicts amygdala reactivity. Nat Neurosci 9, 1362–1363 (2006). https://doi.org/10.1038/nn1780
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