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Nonlinear, binocular interactions underlying flow field selectivity of a motion-sensitive neuron

Nature Neurosciencevolume 9pages13121320 (2006) | Download Citation

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Abstract

Neurons in many species have large receptive fields that are selective for specific optic flow fields. Here, we studied the neural mechanisms underlying flow field selectivity in lobula plate tangential cells (LPTCs) of the blowfly. Among these cells, the H2 cell responds preferentially to visual stimuli approximating rotational optic flow. Through double recordings from H2 and many other LPTCs, we characterized a bidirectional commissural pathway that allows visual information to be shared between the hemispheres. This pathway is mediated by axo-axonal electrical coupling of H2 and the horizontal system equatorial (HSE) cell located in the opposite hemisphere. Using single-cell ablations, we found that this pathway is sufficient to allow H2 to amplify and attenuate dendritic input during binocular visual stimuli. This is accomplished through a modulation of H2's membrane potential by input from the contralateral HSE cell, which scales the firing rate of H2 during visual stimulation but is not sufficient to induce action potentials.

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Acknowledgements

We would like to thank R.H. Masland for carefully reading an earlier version of this manuscript.

Author information

Author notes

    • Karl Farrow

    Present address: Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, Thier 429, Boston, Massachusetts, 02114, USA

  1. Karl Farrow and Juergen Haag: These authors contributed equally to this work.

Affiliations

  1. Department of Systems and Computational Neurobiology, Max-Planck-Institute of Neurobiology, Am Klopferspitz 18, Martinsried, 82152, Germany

    • Karl Farrow
    • , Juergen Haag
    •  & Alexander Borst

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Contributions

K.F. and J.H. performed the experiments and analyzed the data. K.F. carried out the computer simulations. K.F., J.H. and A.B. jointly planned the experiments, discussed the results and wrote the manuscript.

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The authors declare no competing financial interests.

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Correspondence to Karl Farrow.

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https://doi.org/10.1038/nn1769