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Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage

Nature Neuroscience volume 9, pages 173179 (2006) | Download Citation

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Abstract

The developmental origin of oligodendrocyte progenitors (OLPs) in the forebrain has been controversial. We now show, by Cre-lox fate mapping in transgenic mice, that the first OLPs originate in the medial ganglionic eminence (MGE) and anterior entopeduncular area (AEP) in the ventral forebrain. From there, they populate the entire embryonic telencephalon including the cerebral cortex before being joined by a second wave of OLPs from the lateral and/or caudal ganglionic eminences (LGE and CGE). Finally, a third wave arises within the postnatal cortex. When any one population is destroyed at source by the targeted expression of diphtheria toxin, the remaining cells take over and the mice survive and behave normally, with a normal complement of oligodendrocytes and myelin. Thus, functionally redundant populations of OLPs compete for space in the developing brain. Notably, the embryonic MGE- and AEP-derived population is eliminated during postnatal life, raising questions about the nature and purpose of the competition.

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Acknowledgements

We thank our colleagues at the Wolfson Institute for Biomedical Research and elsewhere for discussion, technical help and advice—especially M. Fruttiger, U. Dennehy and R. Taveira-Marques. We thank I. Maxwell for supplying the DTA plasmid. This work was funded by the UK Medical Research Council, the Wellcome Trust Functional Genomics Initiative and a Wellcome Trust Prize Studentship (M.F.).

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Affiliations

  1. Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK.

    • Nicoletta Kessaris
    • , Matthew Fogarty
    • , Palma Iannarelli
    • , Matthew Grist
    •  & William D Richardson
  2. Institut für Biochemie, Emil-Fischer Zentrum, Fahrstrasse 17, 91054 Erlangen, Germany.

    • Michael Wegner

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The authors declare no competing financial interests.

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Correspondence to Nicoletta Kessaris or William D Richardson.

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    Cre deleter lines.

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DOI

https://doi.org/10.1038/nn1620

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