Brief Communication | Published:

Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses

Nature Neuroscience volume 9, pages 2325 (2006) | Download Citation

Subjects

Abstract

Trial-to-trial variability in the blood oxygen level–dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Nat. Neurosci. 6, 414–420 (2003).

  2. 2.

    & Proc. Natl. Acad. Sci. USA 102, 5612–5617 (2005).

  3. 3.

    et al. Science 281, 1188–1191 (1998).

  4. 4.

    , , & Neuron 35, 975–987 (2002).

  5. 5.

    , , & Science 273, 1868–1871 (1996).

  6. 6.

    , & Nature 431, 573–578 (2004).

  7. 7.

    & J. Neurosci. 19, 2209–2223 (1999).

  8. 8.

    , , & Magn. Reson. Med. 34, 537–541 (1995).

  9. 9.

    et al. Proc. Natl. Acad. Sci. USA 102, 9673–9678 (2005).

  10. 10.

    et al. AJNR Am. J. Neuroradiol. 21, 1636–1644 (2000).

  11. 11.

    , & Neuroimage 7, 119–132 (1998).

  12. 12.

    , , , & Hum. Brain Mapp. 15, 247–262 (2002).

  13. 13.

    et al. Nat. Neurosci. 4, 651–655 (2001).

  14. 14.

    Proc. Natl. Acad. Sci. USA 93, 602–608 (1996).

  15. 15.

    in The Visual Neurosciences (eds. Chalupa, L.M. & Werner, J.S.) 1603–1615 (MIT Press, Cambridge, Massachusetts, 2003).

Download references

Acknowledgements

This work was supported by the US National Institutes of Health grant NS06833.

Author information

Affiliations

  1. Department of Radiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA.

    • Michael D Fox
    • , Abraham Z Snyder
    • , Jeffrey M Zacks
    •  & Marcus E Raichle
  2. Department of Neurology, Washington University in St. Louis, St. Louis, Missouri 63110, USA.

    • Abraham Z Snyder
    •  & Marcus E Raichle
  3. Department of Psychology, Washington University in St. Louis, St. Louis, Missouri 63110, USA.

    • Jeffrey M Zacks
  4. Departments of Anatomy and Neurobiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA.

    • Marcus E Raichle
  5. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63110, USA.

    • Marcus E Raichle

Authors

  1. Search for Michael D Fox in:

  2. Search for Abraham Z Snyder in:

  3. Search for Jeffrey M Zacks in:

  4. Search for Marcus E Raichle in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michael D Fox.

Supplementary information

PDF files

  1. 1.

    Supplementary Fig. 1

    Reproduction of figure 2 from the article for each of the 14 subjects.

  2. 2.

    Supplementary Table 1

    Regional statistics for each subject

  3. 3.

    Supplementary Table 2

    Changes in signal power, noise power, and signal/noise ratio for LMC event-related responses upon removal of RMC activity for each subject

  4. 4.

    Supplementary Table 3

    Response magnitudes binned by activity in the right somatomotor cortex.

  5. 5.

    Supplementary Methods

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/nn1616

Further reading