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Matching storage and recall: hippocampal spike timing–dependent plasticity and phase response curves

Nature Neuroscience volume 8, pages 16771683 (2005) | Download Citation

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Abstract

Hippocampal area CA3 is widely considered to function as an autoassociative memory. However, it is insufficiently understood how it does so. In particular, the extensive experimental evidence for the importance of carefully regulated spiking times poses the question as to how spike timing–based dynamics may support memory functions. Here, we develop a normative theory of autoassociative memory encompassing such network dynamics. Our theory specifies the way that the synaptic plasticity rule of a memory constrains the form of neuronal interactions that will retrieve memories optimally. If memories are stored by spike timing–dependent plasticity, neuronal interactions should be formalized in terms of a phase response curve, indicating the effect of presynaptic spikes on the timing of postsynaptic spikes. We show through simulation that such memories are competent analog autoassociators and demonstrate directly that the attributes of phase response curves of CA3 pyramidal cells recorded in vitro qualitatively conform with the theory.

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Acknowledgements

We thank B. Gutkin, D. MacKay and E. Shea-Brown for valuable discussions and E.O. Mann and D. McLelland for their help with Igor procedures. This work was supported by the Gatsby Charitable Foundation (M.L., P.D.), the European Bayesian-Inspired Brain and Artefacts project (M.L., P.D.), the Biotechnology and Biological Sciences Research Council (J.K., O.P.), the Kwanjung Educational Foundation, Korea (J.K.) and the Oxford University Clarendon Fund (J.K.).

Author information

Affiliations

  1. Gatsby Computational Neuroscience Unit, University College London, 17 Queen Square, London WC1N 3AR, UK.

    • Máté Lengyel
    •  & Peter Dayan
  2. University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK.

    • Jeehyun Kwag
    •  & Ole Paulsen

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Máté Lengyel.

Supplementary information

PDF files

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    Supplementary Fig. 1

    Recall performance in adversarial settings.

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    Supplementary Fig. 2

    Consequences of a broad, smoothly varying STDP curve on the optimal coupling function and phase response curves.

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    Supplementary Fig. 3

    Effect of increased oscillatory frequency on the PRC.

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    Supplementary Fig. 4

    Burst-based PRCs.

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    Supplementary Methods

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    Supplementary Note

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DOI

https://doi.org/10.1038/nn1561

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