The cerebral cortex is interconnected with two major subcortical structures: the basal ganglia and the cerebellum. How and where cerebellar circuits interact with basal ganglia circuits has been a longstanding question. Using transneuronal transport of rabies virus in macaques, we found that a disynaptic pathway links an output stage of cerebellar processing, the dentate nucleus, with an input stage of basal ganglia processing, the striatum.
Subscribe to Journal
Get full journal access for 1 year
only $18.75 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Alexander, G.E., DeLong, M.R. & Strick, P.L. Annu. Rev. Neurosci. 9, 357–381 (1986).
Graybiel, A.M. Neurobiol. Learn. Mem. 70, 119–136 (1998).
Masterman, D.L. & Cummings, J.L.J. Psychopharmacology 11, 107–114 (1997).
Middleton, F.A. & Strick, P.L. Brain Res. Brain Res. Rev. 31, 236–250 (2000).
Schmahmann, J.D. The Cerebellum and Cognition (Academic, San Diego, 1997).
Jones, E.G. The Thalamus (Plenum, New York, 1985).
Percheron, G., Francois, C., Talbi, B., Yelnik, J. & Fenelon, G. Brain Res. Brain Res. Rev. 22, 93–181 (1996).
Kelly, R.M. & Strick, P.L. J. Neurosci. Methods 103, 63–71 (2000).
Middleton, F.A. & Strick, P.L. J. Neurosci. 21, 700–712 (2001).
Dum, R.P., Li, C. & Strick, P.L. Ann. NY Acad. Sci. 978, 289–301 (2002).
Clower, D.M., Dum, R.P. & Strick, P.L. Cereb. Cortex 15, 913–920 (2005).
Smith, Y., Raju, D.V., Pare, J.F. & Sidibe, M. Trends Neurosci. 27, 520–527 (2004).
Ichinohe, N., Mori, F. & Shoumura, K. Brain Res. 880, 191–197 (2000).
Wichmann, T. & DeLong, M.R. Curr. Opin. Neurobiol. 6, 751–758 (1996).
Doya, K. Curr. Opin. Neurobiol. 10, 732–739 (2000).
This work was supported by the Veterans Affairs Medical Research Service; the National Parkinson Foundation; US Department of Health and Human Services grants MH56661, NS047126, RR018604 (P.L.S.) and a long-term fellowship from the Human Frontier Science Program Organization (E.H.). We thank B. Dietzschold and M. Schnell (Thomas Jefferson University, Philadelphia) for supplying rabies virus and A. Wandeler (Animal Disease Research Institute, Nepean, Ontario, Canada) for supplying antibodies to rabies. We thank M. Page for developing the computer programs; C. Lovell, K. McDonald, M. O'Malley, M. Ratajeski and M. Watach for their technical assistance; and D. Akkal, F. Delis, R.P. Dum, D. Hoffman, and J.-A. Rathelot for scientific discussions.
The authors declare no competing financial interests.
Experimental paradigm. (PDF 240 kb)
Injection site in putamen, and thalamic neurons labeled by retrograde transneuronal transport of virus from Gpe. (PDF 325 kb)
The cerebellar pathway to the basal ganglia. (PDF 134 kb)
About this article
Cite this article
Hoshi, E., Tremblay, L., Féger, J. et al. The cerebellum communicates with the basal ganglia. Nat Neurosci 8, 1491–1493 (2005). https://doi.org/10.1038/nn1544
Frontiers in Neuroinformatics (2020)
Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease
Acta Neuropathologica Communications (2020)
The Cerebellum (2020)
Larger, but not better, motor adaptation ability inherent in medicated Parkinson’s disease patients revealed by a smart-device-based study
Scientific Reports (2020)