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The cerebellum communicates with the basal ganglia

Nature Neuroscience volume 8, pages 14911493 (2005) | Download Citation

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Abstract

The cerebral cortex is interconnected with two major subcortical structures: the basal ganglia and the cerebellum. How and where cerebellar circuits interact with basal ganglia circuits has been a longstanding question. Using transneuronal transport of rabies virus in macaques, we found that a disynaptic pathway links an output stage of cerebellar processing, the dentate nucleus, with an input stage of basal ganglia processing, the striatum.

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Acknowledgements

This work was supported by the Veterans Affairs Medical Research Service; the National Parkinson Foundation; US Department of Health and Human Services grants MH56661, NS047126, RR018604 (P.L.S.) and a long-term fellowship from the Human Frontier Science Program Organization (E.H.). We thank B. Dietzschold and M. Schnell (Thomas Jefferson University, Philadelphia) for supplying rabies virus and A. Wandeler (Animal Disease Research Institute, Nepean, Ontario, Canada) for supplying antibodies to rabies. We thank M. Page for developing the computer programs; C. Lovell, K. McDonald, M. O'Malley, M. Ratajeski and M. Watach for their technical assistance; and D. Akkal, F. Delis, R.P. Dum, D. Hoffman, and J.-A. Rathelot for scientific discussions.

Author information

Affiliations

  1. Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

    • Eiji Hoshi
    • , Peter L Carras
    •  & Peter L Strick
  2. Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

    • Eiji Hoshi
    • , Peter L Carras
    •  & Peter L Strick
  3. Tamagawa University Research Institute, Machida, Tokyo 194-8610 Japan.

    • Eiji Hoshi
  4. Neurologie et Thérapeutique expérimentale (INSERM U679), Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris CEDEX 13, France.

    • Léon Tremblay
    •  & Jean Féger
  5. Pittsburgh Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15261, USA.

    • Peter L Strick

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Peter L Strick.

Supplementary information

PDF files

  1. 1.

    Supplementary Fig. 1

    Experimental paradigm.

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    Supplementary Fig. 2

    Injection site in putamen, and thalamic neurons labeled by retrograde transneuronal transport of virus from Gpe.

  3. 3.

    Supplementary Fig. 3

    The cerebellar pathway to the basal ganglia.

  4. 4.

    Supplementary Methods

  5. 5.

    Supplementary Discussion

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DOI

https://doi.org/10.1038/nn1544

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