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Regret and its avoidance: a neuroimaging study of choice behavior

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Abstract

Human decisions can be shaped by predictions of emotions that ensue after choosing advantageously or disadvantageously. Indeed, anticipating regret is a powerful predictor of future choices. We measured brain activity using functional magnetic resonance imaging (fMRI) while subjects selected between two gambles wherein regret was induced by providing information about the outcome of the unchosen gamble. Increasing regret enhanced activity in the medial orbitofrontal region, the anterior cingulate cortex and the hippocampus. Notably, across the experiment, subjects became increasingly regret-aversive, a cumulative effect reflected in enhanced activity within medial orbitofrontal cortex and amygdala. This pattern of activity reoccurred just before making a choice, suggesting that the same neural circuitry mediates direct experience of regret and its anticipation. These results demonstrate that medial orbitofrontal cortex modulates the gain of adaptive emotions in a manner that may provide a substrate for the influence of high-level emotions on decision making.

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References

  1. 1

    Roese, N.J. & Olson, J.M. What Might Have Been: The Social Psychology of Counterfactual Thinking (Erlbaum, Mahwah, New Jersey, USA, 1995).

  2. 2

    Byrne, R.M.J. Mental models and counterfactual thinking. Trends Cogn. Sci. 6, 426–445 (2002).

  3. 3

    Kahneman, D. & Tversky, A. The psychology of preferences. Sci. Am. 246, 136–142 (1982).

  4. 4

    Kahneman, D. & Miller, D. Norm theory: comparing reality to its alternatives. Psychol. Rev. 93, 136–153 (1986).

  5. 5

    Mellers, B., Schwartz, A. & Ritov, I. Emotion-based choice. J. Exp. Psychol. Gen. 128, 332–345 (1999).

  6. 6

    Zeelenberg, M. & van Dijk, E. On the comparative nature of regret. in The Psychology of Counterfactual Thinking (eds. Mandel, D., Hilton D. & Catelani, P.) 147–161 (Routledge, London, 2005).

  7. 7

    Bell, D.E. Regret in decision-making under uncertainty. Oper. Res. 30, 961–981 (1982).

  8. 8

    Loomes, G. & Sugden, R. Regret theory: an alternative theory of rational choice under uncertainty. Econ. J. 92, 805–824 (1982).

  9. 9

    Bell, D.E. Disappointment in decision making under uncertainty. Oper. Res. 33, 1–27 (1985).

  10. 10

    Loomes, G. & Sugden, R. Disappointment and dynamic inconsistency in choice under uncertainty. Rev. Econ. Stud. 53, 271–282 (1986).

  11. 11

    Zeelenberg, M. et al. Consequences of regret aversion: effects of expected feedback on risky decision making. Organ. Behav. Hum. Decis. Process. 65, 148–158 (1996).

  12. 12

    Gottfried, J.A. & Dolan, R.J. Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value. Nat. Neurosci. 7, 1144–1152 (2004).

  13. 13

    Rolls, E.T. The orbitofrontal cortex and reward. Cereb. Cortex 10, 284–294 (2000).

  14. 14

    Tremblay, L. & Schultz, W. Relative reward preference in primate orbitofrontal cortex. Nature 398, 704–708 (1999).

  15. 15

    Elliott, R. et al. Dissociable neural responses in human reward systems. J. Neurosci. 20, 6159–6165 (2000).

  16. 16

    Kringelbach, M. & Rolls, E. The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Prog. Neurobiol. 72, 341–372 (2004).

  17. 17

    Breiter, H.C., Ahron, I., Kahneman, D., Dale, A. & Shizgal, P. Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron 30, 619–639 (2001).

  18. 18

    O'Doherty, J. et al. Abstract reward and punishment representations in the human orbitofrontal cortex. Nat. Neurosci. 4, 95–102 (2001).

  19. 19

    Camille, N. et al. The involvement of the orbitofrontal cortex in the experience of regret. Science 304, 1167–1170 (2004).

  20. 20

    Corlett, P.R. et al. Prediction error during retrospective revaluation of causal associations in humans: fMRI evidence in favor of an associative model of learning. Neuron 44, 877–888 (2004).

  21. 21

    Schultz, W., Dayan, P. & Montague, P.R. A neural substrate of prediction and reward. Science 275, 1593–1599 (1997).

  22. 22

    Miceli, M. & Castelfranchi, C. The mind and the future: The (negative) power of expectations. Theory Psychol. 12, 335–366 (2002).

  23. 23

    Peyron, R., Laurent, B. & Garcia-Larrea, L. Functional imaging of brain responses to pain. A review and meta-analysis. Neurophysiol. Clin. 30, 263–288 (2000).

  24. 24

    Gobel, S.M., Johansen-Berg, H., Behrens, T. & Rushworth, M.F.S. Response-selection-related parietal activation during number comparison. J. Cogn. Neurosci. 16, 1536–1551 (2004).

  25. 25

    Tobler, P.N., Fiorillo, C.D. & Schultz, W. Adaptive coding of reward value by dopamine neurons. Science 307, 1642–1645 (2005).

  26. 26

    Dreher, J.C., Kohn, P. & Berman, K.F. Neural coding of distinct statistical properties of reward information in humans. Cereb. Cortex (in the press).

  27. 27

    Holroyd, C.B. et al. Dorsal anterior cingulated cortex shows fMRIresponse to internal and external error signal. Nat. Neurosci. 7, 497–498 (2004).

  28. 28

    Shidara, M. & Richmond, B.J. Anterior cingulated: single neuronal signal related to degree of reward expectancy. Science 296, 1709–1711 (2002).

  29. 29

    Berns, G.S., McClure, S.M., Pagnoni, G. & Montague, P.R. Predictability modulates human brain response to reward. J. Neurosci. 21, 2793–2798 (2001).

  30. 30

    Gottfried, J.A., O'Doherty, J. & Dolan, R.J. Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science 301, 1104–1107 (2003).

  31. 31

    Elliott, R., Newman, J.L., Longe, O.A. & Deakin, J.F. Differential response patterns in the striatum and orbitofrontal cortex to financial reward in humans: a parametric functional magnetic resonance imaging study. J. Neurosci. 23, 303–307 (2003).

  32. 32

    Bechara, A., Tranel, D. & Damasio, H. Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain 123, 2189–2202 (2000).

  33. 33

    Schoenbaum, G., Chiba, A.A. & Gallagher, M. Orbitofrontal cortex and basolateral amygdala encode experience outcomes during learning. Nat. Neurosci. 1, 155–159 (1998).

  34. 34

    Rolls, E.T., Hornak, J., Wade, D. & McGrath, J. Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. J. Neurol. Neurosurg. Psychiatry 57, 1518–1524 (1994).

  35. 35

    Dorris, M.C. & Glimcher, P.W. Activity in posterior parietal cortex is correlated with the relative subjective desirability of action. Neuron 44, 365–378 (2004).

  36. 36

    Bush, G., Phan, L. & Posner, M.I. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 4, 215–222 (2000).

  37. 37

    Critchley, H.D. The human cortex responds to an interoceptive challenge. Proc. Natl. Acad. Sci. USA 101, 6333–6334 (2004).

  38. 38

    Carter, C.S., Botvinick, M.M. & Cohen, J.D. The contribution of the anterior cingulate cortex to executive processes in cognition. Rev. Neurosci. 10, 49–57 (1999).

  39. 39

    Kiehl, K.A., Liddle, P.F. & Hopfinger, J.B. Error processing and the rostral anterior cingulate: an event-related fMRI study. Psychophysiology 37, 216–223 (2000).

  40. 40

    Garavan, H., Ross, T.J., Murphy, K., Roche, R.A. & Stein, E.A. Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction. Neuroimage 17, 1820–1829 (2002).

  41. 41

    Kerns, J.G. et al. Anterior cingulate conflict monitoring and adjustments in control. Science 303, 1023–1026 (2004).

  42. 42

    Lane, R.D. et al. Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex. J. Cogn. Neurosci. 10, 525–535 (1998).

  43. 43

    Phan, K.L., Liberzon, I., Welsh, R.C., Britton, J.C. & Taylor, S.F. Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures. Neuropsychopharmacology 28, 1344–1350 (2003).

  44. 44

    Critchley, H.D. et al. Activity in the human brain predicting differential heart rate responses to emotional facial expressions. Neuroimage 24, 751–762 (2005).

  45. 45

    Critchley, H.D. et al. Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. Brain 126, 2139–2152 (2003).

  46. 46

    Deichmann, R., Gottfried, J.A., Hutton, C. & Turner, R. Optimized EPI for fMRI studies of the orbitofrontal cortex. Neuroimage 19, 430–441 (2003).

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Acknowledgements

This work was supported by grants from the Human Frontier Science Program (RGP 56/2005), the Action Concertée Incitative, Systemes Complexes from the Centre National de la Recherche Scientifique to A.S. and G.C., the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior to M.J., a Wellcome Trust Programme Grant to R.J.D. and a Wellcome Senior Fellowship in Clinical Science to H.D.C.

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Competing interests

The authors declare no competing financial interests.

Correspondence to Angela Sirigu or Raymond J Dolan.

Supplementary information

  1. Supplementary Figure 1

    Activity at choice in partial-feedback choose (PC) condition when subjects chose minimizing future disappointment vs. maximization of expected values. (PDF 132 kb)

  2. Supplementary Figure 2

    Activity at choice in complete-feedback choose (CC) condition when subjects chose minimizing future regret vs. maximization of expected values. (PDF 130 kb)

  3. Supplementary Figure 3

    Smoothed normalized EPI images and corresponding locations in a normalized structural template image. (PDF 216 kb)

  4. Supplementary Table 1

    Pairs of gambles used in the fMRI experiment. (PDF 60 kb)

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DOI

https://doi.org/10.1038/nn1514

Further reading

Figure 1: Experimental design.
Figure 2: Activity at outcome is related to win and loss.
Figure 3: The effect of the unobtained outcome: counterfactual processing of value.
Figure 4: Regret and relief.
Figure 5: Activity at choice: learning from the experience of regret.