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How can drug addiction help us understand obesity?

To the degree that drugs and food activate common reward circuitry in the brain, drugs offer powerful tools for understanding the neural circuitry that mediates food-motivated habits and how this circuitry may be hijacked to cause appetitive behaviors to go awry.

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Figure 1: Dopaminergic pathways.
Figure 2
Figure 3: Role of dopamine D2 receptors in obesity.


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The authors thank C. Kassed for her assistance in preparing the manuscript.

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Volkow, N., Wise, R. How can drug addiction help us understand obesity?. Nat Neurosci 8, 555–560 (2005).

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