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Spatial selectivity in human ventrolateral prefrontal cortex


The functional organization of lateral prefrontal cortex is not well understood, and there is debate as to whether the dorsal and ventral aspects mediate distinct spatial and non-spatial functions, respectively. We show for the first time that recordings from human ventrolateral prefrontal cortex show spatial selectivity, supporting the idea that ventrolateral prefrontal cortex is involved in spatial processing. Our results also indicate that prefrontal cortex may be a source of control signals for neuroprosthetic applications.

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Figure 1: Human ventrolateral PFC shows spatial selectivity during target presentation.
Figure 2: Human ventrolateral PFC shows spatial selectivity during the movement period.
Figure 3: Using bilateral recordings improves decoding accuracy.


  1. Miller, E.K. Nat. Rev. Neurosci. 1, 59–65 (2000).

    Article  CAS  Google Scholar 

  2. Fuster, J.M., Bodner, M. & Kroger, J.K. Nature 405, 347–351 (2000).

    Article  CAS  Google Scholar 

  3. Funahashi, S., Chafee, M.V. & Goldman-Rakic, P.S. Nature 365, 753–756 (1993).

    Article  CAS  Google Scholar 

  4. Leung, H.C., Gore, J.C. & Goldman-Rakic, P.S. J. Cogn. Neurosci. 14, 659–671 (2002).

    Article  Google Scholar 

  5. O'Scalaidhe, S.P., Wilson, F.A. & Goldman-Rakic, P.S. Science 278, 1135–1138 (1997).

    Article  CAS  Google Scholar 

  6. Wilson, F.A., O'Scalaidhe, S.P. & Goldman-Rakic, P.S. Science 260, 1955–1958 (1993).

    Article  CAS  Google Scholar 

  7. Courtney, S., Ungerleider, L., Keil, K. & Haxby, J. Cereb. Cortex 6, 39–49 (1996).

    Article  CAS  Google Scholar 

  8. Rao, S.C., Rainer, G. & Miller, E.K. Science 276, 821–824 (1997).

    Article  CAS  Google Scholar 

  9. Deco, G., Rolls, E.T. & Horwitz, B. J. Cogn. Neurosci. 16, 683–701 (2004).

    Article  Google Scholar 

  10. Goodale, M.A. & Milner, A.D. Trends Neurosci. 15, 20–25 (1992).

    Article  CAS  Google Scholar 

  11. Toth, L.J. & Assad, J.A. Nature 415, 165–168 (2002).

    Article  CAS  Google Scholar 

  12. Sabes, P.N., Breznen, B. & Andersen, R.A. J. Neurosci. 88, 1815–1829 (2002).

    Google Scholar 

  13. Mehring, C. et al. Nat. Neurosci. 6, 1253–1254 (2003).

    Article  CAS  Google Scholar 

  14. Pesaran, B., Pezaris, J.S., Sahani, M., Mitra, P.P. & Andersen, R.A. Nat. Neurosci. 5, 805–811 (2002).

    Article  CAS  Google Scholar 

  15. Leuthardt, E.C., Schalk, G., Wolpaw, J.R., Ojemann, J.G. & Moran, D.W. J. Neural Eng. 1, 63–71 (2004).

    Article  Google Scholar 

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We thank S. Musallam, A. Gail, B. Pesaran and H. Glidden for helpful discussion. The authors acknowledge support from the US Defense Advanced Research Projects Agency, National Eye Institute, the Boswell Foundation, Office of Naval Research and National Institute of Neurological Disorders and Stroke.

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Rizzuto, D., Mamelak, A., Sutherling, W. et al. Spatial selectivity in human ventrolateral prefrontal cortex. Nat Neurosci 8, 415–417 (2005).

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