Brief Communication

Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

  • Nature Neuroscience volume 7, pages 493494 (2004)
  • doi:10.1038/nn1226
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Abstract

The hypothalamic arcuate nucleus (ARC) integrates and responds to satiety and hunger signals and forms the origins of the central neural response to perturbations in energy balance. Here we show that rat ARC neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin. We propose a neuron-specific signaling mechanism through which central and peripheral signals engage the central neural anabolic drive.

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Acknowledgements

Financial support from the Biotechnology and Biological Sciences Research Council (BBSRC), the Foundation for Prader-Willi Research and British Heart Foundation (BHF) is gratefully acknowledged.

Author information

Affiliations

  1. Department of Biological Sciences, Gibbet Hill Campus, University of Warwick, Coventry CV4 7AL, UK.

    • Marco van den Top
    • , Kevin Lee
    • , Andrew D Whyment
    • , Andrew M Blanks
    •  & David Spanswick

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to David Spanswick.

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