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Microgliosis: the questions shape the answers

Brain microglia increase their numbers in response to threats. Some of these cells were thought to enter the CNS from the blood, but two new studies suggest that experimental confounds could in part account for such results.

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Figure 1: Irradiation chimerism can generate a mouse in which genetic characteristics of circulating microglial precursors differ from those of brain microglia (right mouse with +/+ circulating cells and −/− brain cells).

Katie Ris-Vicari

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Ransohoff, R. Microgliosis: the questions shape the answers. Nat Neurosci 10, 1507–1509 (2007). https://doi.org/10.1038/nn1207-1507

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