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Microgliosis: the questions shape the answers

Brain microglia increase their numbers in response to threats. Some of these cells were thought to enter the CNS from the blood, but two new studies suggest that experimental confounds could in part account for such results.

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Figure 1: Irradiation chimerism can generate a mouse in which genetic characteristics of circulating microglial precursors differ from those of brain microglia (right mouse with +/+ circulating cells and −/− brain cells).

Katie Ris-Vicari


  1. Ajami, B., Bennett, J., Krieger, C., Tetzlaff, W. & Rossi, F. Nat. Neurosci. 10, 1538–1543 (2007).

    Article  CAS  Google Scholar 

  2. Mildner, A. et al. Nat. Neurosci. 10, 1544–1553 (2007).

    Article  CAS  Google Scholar 

  3. Ting, J.P., Nixon, D.F., Weiner, L.P. & Frelinger, J.A. Immunogenetics 17, 295–301 (1983).

    Article  CAS  Google Scholar 

  4. Matsumoto, Y. & Fujiwara, M. J. Neuroimmunol. 17, 71–82 (1987).

    Article  CAS  Google Scholar 

  5. Bauer, J. et al. Glia 15, 437–446 (1995).

    Article  CAS  Google Scholar 

  6. Hickey, W.F. & Kimura, H. Science 239, 290–292 (1988).

    Article  CAS  Google Scholar 

  7. Greter, M. et al. Nat. Med. 11, 328–334 (2005).

    Article  CAS  Google Scholar 

  8. Ponomarev, E.D., Shriver, L.P., Maresz, K. & Dittel, B.N. J. Neurosci. Res. 81, 374–389 (2005).

    Article  CAS  Google Scholar 

  9. Flugel, A., Bradl, M., Kreutzberg, G.W. & Graeber, M.B. J. Neurosci. Res. 66, 74–82 (2001).

    Article  CAS  Google Scholar 

  10. Ford, A.L., Goodsall, A.L., Hickey, W.F. & Sedgwick, J.D. J. Immunol. 154, 4309–4321 (1995).

    CAS  PubMed  Google Scholar 

  11. Massengale, M., Wagers, A.J., Vogel, H. & Weissman, I.L. J. Exp. Med. 201, 1579–1589 (2005).

    Article  CAS  Google Scholar 

  12. Gartner, S. Science 287, 602–604 (2000).

    Article  CAS  Google Scholar 

  13. Massberg, S. et al. Cell (in the press) (2007).

    Google Scholar 

  14. Simard, A.R. & Rivest, S. FASEB J. 18, 998–1000 (2004).

    Article  CAS  Google Scholar 

  15. Tsou, C.L. et al. J. Clin. Invest. 117, 902–909 (2007).

    Article  CAS  Google Scholar 

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Ransohoff, R. Microgliosis: the questions shape the answers. Nat Neurosci 10, 1507–1509 (2007).

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