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High times for memory: cannabis disrupts temporal coordination among hippocampal neurons

Exogenous cannabinoid receptor agonists impair hippocampus-dependent learning and decrease the power of hippocampal electroencephalographic activity. A new paper shows that cannabinoids desynchronize neuronal assemblies without affecting average firing rates, and that this effect correlates with memory deficits in individuals.

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Figure 1: Cell assemblies and the effect of cannabinoids according to Robbe and colleagues1.


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Soltesz, I., Staley, K. High times for memory: cannabis disrupts temporal coordination among hippocampal neurons. Nat Neurosci 9, 1461–1463 (2006).

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