The Rho-family GTPases act downstream of axon guidance receptors, controlling proteins that remodel the cytoskeleton. New work now suggests that these GTPases also team up to regulate activation of the semaphorin-3A receptor itself.
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Garrity, P. Tinker to Evers to Chance: semaphorin signaling takes teamwork. Nat Neurosci 8, 1635–1636 (2005). https://doi.org/10.1038/nn1205-1635
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DOI: https://doi.org/10.1038/nn1205-1635
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