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Flipping the switch from electrical to chemical communication

Immature neurons in many brain regions are electrically coupled through gap junctions, which are lost as chemical synaptic transmission matures. This developmental uncoupling is now shown to require NMDA receptor activation.

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Figure 1: NMDA receptor–mediated uncoupling of developing hypothalamic neurons.

Ann Thomson


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Kandler, K., Thiels, E. Flipping the switch from electrical to chemical communication. Nat Neurosci 8, 1633–1634 (2005).

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