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Flipping the switch from electrical to chemical communication

Nature Neuroscience volume 8, pages 16331634 (2005) | Download Citation

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Immature neurons in many brain regions are electrically coupled through gap junctions, which are lost as chemical synaptic transmission matures. This developmental uncoupling is now shown to require NMDA receptor activation.

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Affiliations

  1. Karl Kandler and Edda Thiels are in the Department of Neurobiology and Center for the Neuronal Basis of Cognition, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA. kkarl@neurobio.pitt.edu or thiels@neurobio.pitt.edu

    • Karl Kandler
    •  & Edda Thiels

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DOI

https://doi.org/10.1038/nn1205-1633

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