Back to the future: carbon dioxide chemoreceptors in the mammalian brain

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Neurons that increase breathing in response to increased CO2 have long been sought along the ventral medullary surface, but not found, until now. Exquisitely CO2-sensitive neurons identified near this site may be the long-lost central chemoreceptors.

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Figure 1: CO2-sensitive neurons in the RTN.

Brad A. Hogdeman

Figure 2: Schematic representation of the distributed, state-dependent central chemoreceptor hypothesis1,12.

Brad A. Hogdeman

References

  1. 1

    Feldman, J.L., Mitchell, G.S. & Nattie, E.E. Annu. Rev. Neurosci. 26, 239–266 (2003).

  2. 2

    Mitchell, R.A., Loeschcke, H.H., Severinghaus, J.W., Richardson, B.W. & Massion, W.H. Ann. NY Acad. Sci. 109, 661–681 (1963).

  3. 3

    Mitchell, R.A., Loeschcke, H.H., Massion, W.H. & Severinghaus, J.W. J. Appl. Physiol. 18, 523–533 (1963).

  4. 4

    Putnam, R.W. Respir. Physiol. 129, 37–56 (2001).

  5. 5

    Xu, F. & Frazier, D.T. Cerebellum 1, 35–40 (2002).

  6. 6

    Ballantyne, D. & Scheid, P. Respir. Physiol. 129, 5–12 (2001).

  7. 7

    Richerson, G.B. Nat. Rev. Neurosci. 5, 449–461 (2004).

  8. 8

    Mulkey, D.K. et al. Nat. Neurosci. 7 1360–1369 (2004)

  9. 9

    Smith, J.C., Morrison, D.E., Ellenberger, H.H., Otto, M.R. & Feldman, J.L. J. Comp. Neurol. 281, 69–96 (1989).

  10. 10

    Li, A., Randall, M. & Nattie, E.E. J. Appl. Physiol. 87, 910–919 (1999).

  11. 11

    Forster, H.V., Ohtake, P.J., Pan, L.G. & Lowry, T.F. Respir. Physiol. 110, 187–197 (1997).

  12. 12

    Nattie, E.E. Respir. Physiol. 129, 257–268 (2001).

  13. 13

    Alheid, G.F., Gray, P.A., Jiang, M.C., Feldman, J.L. & McCrimmon, D.R. J. Neurocytol. 31, 693–717 (2002).

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Mitchell, G. Back to the future: carbon dioxide chemoreceptors in the mammalian brain. Nat Neurosci 7, 1288–1290 (2004) doi:10.1038/nn1204-1288

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