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When the going gets tough, the cingulate gets going

Nature Neuroscience volume 7, pages 1285–1287 (2004)Cite this article

Despite extensive study, the exact role of human anterior cingulate cortex in forming behavioral strategies is still controversial. In this issue, Williams and colleagues describe a rare opportunity to test a hypothesis about the function of this brain area in humans, by not only recording from single neurons, but also monitoring behavior immediately after surgical ablation of the area.

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Figure 1: Experimental setup of Williams et al.

Ann Thompson

Figure 2: Example trial sequence.

Ann Thompson

References

  1. Ridderinkhof, K.R., Ullsperger, M., Crone, E.A. & Nieuwenhuis, S. Science 306, 443–447 (2004).

    Article  CAS  Google Scholar 

  2. Miltner, W.H.R., Braun, C.H. & Coles, M.G.H. J. Cogn. Neurosci. 9, 788–798 (1997).

    Article  CAS  Google Scholar 

  3. Ullsperger, M. & von Cramon, D.Y. Cortex 40, 593–604 (2004).

    Article  Google Scholar 

  4. Carter, C.S. et al. Science 280, 747–749 (1998).

    Article  CAS  Google Scholar 

  5. Holroyd, C. & Coles, M.G.H. Psychol. Rev. 109, 679–709 (2002).

    Article  Google Scholar 

  6. Gehring, W.J. & Willoughby, A.R. Science 295, 2279–2282 (2002).

    Article  CAS  Google Scholar 

  7. Williams, Z.M., Bush, G., Rauch, S.L., Cosgrove, G.R. & Eskandar, E.N. Nat. Neurosci. 7, 1370–1375 (2004).

    Article  CAS  Google Scholar 

  8. Bush, G. et al. Proc. Natl. Acad. Sci. USA 99, 523–528 (2002).

    Article  CAS  Google Scholar 

  9. Critchley, H.D. et al. Brain 126, 2139–2152 (2003).

    Article  Google Scholar 

  10. Kim C.H. et al. Acta Psychiatry Scand. 107, 283–290 (2003).

    Article  Google Scholar 

  11. Penfield, W. & Jasper, H. Epilepsy and the Functional Anatomy of the Human Brain (Little and Brown, Boston, 1954).

    Book  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA

    William J Gehring

  2. Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA

    Stephan F Taylor

Authors
  1. William J Gehring
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  2. Stephan F Taylor
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Gehring, W., Taylor, S. When the going gets tough, the cingulate gets going. Nat Neurosci 7, 1285–1287 (2004). https://doi.org/10.1038/nn1204-1285

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