Specifying motor neurons: up and down and back to front

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A recent study in Nature shows that the columnar fate of motor neurons in the embryonic spinal cord is imposed by cross-repressive patterns of Hox-c expression. This Hox expression is in turn controlled by graded FGF signaling.

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Figure 1: Motor neuron specification in the dorsoventral and rostrocaudal axis of the spinal cord.

Debbie Maizels

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Harris, W. Specifying motor neurons: up and down and back to front. Nat Neurosci 6, 1247–1249 (2003) doi:10.1038/nn1203-1247

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