Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Specifying motor neurons: up and down and back to front

Nature Neuroscience volume 6, pages 1247–1249 (2003)Cite this article

A recent study in Nature shows that the columnar fate of motor neurons in the embryonic spinal cord is imposed by cross-repressive patterns of Hox-c expression. This Hox expression is in turn controlled by graded FGF signaling.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Motor neuron specification in the dorsoventral and rostrocaudal axis of the spinal cord.

Debbie Maizels

References

  1. Tosney, K.W., Hotary, K.B. & Lance-Jones, C. Bioessays 17, 379–382 (1995).

    Article  CAS  Google Scholar 

  2. Dasen, J., Liu, J.-P. & Jessell, T. Nature 425, 926–933 (2003).

    Article  CAS  Google Scholar 

  3. Novitch, B.G., Wichterle, H., Jessell, T.M. & Sockanathan, S. Neuron 40, 81–95 (2003).

    Article  CAS  Google Scholar 

  4. Diez del Corral, R. et al. Neuron 40, 65–79 (2003).

    Article  CAS  Google Scholar 

  5. Ensini, M., Tsuchida, T.N., Belting, H.G. & Jessell, T.M. Development 125, 969–982 (1998).

    CAS  PubMed  Google Scholar 

  6. Liu, J.P., Laufer, E. & Jessell, T.M. Neuron 32, 997–1012 (2001).

    Article  CAS  Google Scholar 

  7. Bel-Vialar, S., Itasaki, N. & Krumlauf, R. Development 129, 5103–5115 (2002).

    CAS  PubMed  Google Scholar 

  8. Jessell, T.M. Nat. Rev. Genet. 1, 20–29 (2000).

    Article  CAS  Google Scholar 

  9. Sockanathan, S., Perlmann, T. & Jessell, T.M. Neuron 40, 97–111 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Anatomy, Cambridge University, Downing Street, Cambridge, CB2 3DY, UK

    William A Harris

Authors
  1. William A Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harris, W. Specifying motor neurons: up and down and back to front. Nat Neurosci 6, 1247–1249 (2003). https://doi.org/10.1038/nn1203-1247

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1203-1247

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing