Stem cells that know their place

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Human neural stem cells could be used to treat many diseases, but a major problem with this approach is that these cells give rise to few neurons in the brain. Now a new priming method increases production of neurons after implantation, including the elusive cholinergic neurons.

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Figure 1: Generation of cholinergic neurons from primed fetal human neural stem cells in the medial septum of adult rat brain.

References

  1. 1

    Cassidy, R. & Frisen, J. Nature 412, 690–691 (2001).

  2. 2

    Bjorklund, L.M. et al. Proc. Natl. Acad. Sci. USA 99, 2344–2349 (2002).

  3. 3

    Kim, J.H. et al. Nature 418, 50–56 (2002).

  4. 4

    Wu, P., Gu, Y., Huang, L.-Y.M. & Tarasenko, Y. Nat. Neurosci. 5, 1271–1278 (2002).

  5. 5

    Doering, L.C. & Snyder, E.Y. J. Neurosci. Res. 61, 597–604 (2000).

  6. 6

    Cao, Q.L. et al. Exp. Neurol. 167, 48–58 (2001).

  7. 7

    Rubio, F.J. et al. Mol. Cell. Neurosci. 16, 1–13 (2000).

  8. 8

    Englund, U. et al. Exp. Neurol. 173, 1–21 (2002).

  9. 9

    Fricker, R.A. et al. J. Neurosci. 19, 5990–6005 (1999).

  10. 10

    Ostenfeld, T. et al. Exp. Neurol. 164, 215–226 (2000).

  11. 11

    Reubinoff, B.E. et al. Nat. Biotechnol. 19, 1134–1140 (2001).

  12. 12

    Patterson, P.H. & Chun, L.L. Dev. Biol. 56, 263–280 (1977).

  13. 13

    Yayon, A. et al. Cell 64, 841–848 (1991).

  14. 14

    Perrimon, N. & Bernfield, M. Nature 404, 725–728 (2000).

  15. 15

    Schwartz, M.A. & Ginsberg, M.H. Nat. Cell Biol. 4, E65–E68 (2002).

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