Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Staining, straining and restraining prions

A recent paper reported the in vitro generation of new prion strains, supporting the idea that 'strain-ness' is encoded in the protein structure itself. This lays the groundwork for a reinvigorated study of prion structure–pathology relationships.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The PMCA process.


  1. Prusiner, S.B. Science 216, 136–144 (1982).

    CAS  Article  Google Scholar 

  2. Aguzzi, A. & Polymenidou, M. Cell 116, 313–327 (2004).

    CAS  Article  Google Scholar 

  3. Saborio, G.P., Permanne, B. & Soto, C. Nature 411, 810–813 (2001).

    CAS  Article  Google Scholar 

  4. Deleault, N.R., Harris, B.T., Rees, J.R. & Supattapone, S. Proc. Natl. Acad. Sci. USA 104, 9741–9746 (2007).

    CAS  Article  Google Scholar 

  5. Castilla, J. et al. Cell 134, 757–768 (2008).

    CAS  Article  Google Scholar 

  6. Weissmann, C. Nature 352, 679–683 (1991).

    CAS  Article  Google Scholar 

  7. Bessen, R.A. & Marsh, R.F. J. Virol. 68, 7859–7868 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Race, R. & Chesebro, B. Nature 392, 770 (1998).

    CAS  Article  Google Scholar 

  9. Zhou, A. & Carrell, R.W. J. Mol. Biol. 375, 36–42 (2008).

    CAS  Article  Google Scholar 

  10. Silveira, J.R. et al. Nature 437, 257–261 (2005).

    CAS  Article  Google Scholar 

  11. Atarashi, R. et al. Nat. Methods 4, 645–650 (2007).

    CAS  Article  Google Scholar 

  12. Mahal, S.P. et al. Proc. Natl. Acad. Sci. USA 104, 20908–20913 (2007).

    CAS  Article  Google Scholar 

  13. Sigurdson, C.J. et al. Nat. Methods 4, 1023–1030 (2007).

    CAS  Article  Google Scholar 

  14. Klohn, P.C., Stoltze, L., Flechsig, E., Enari, M. & Weissmann, C. Proc. Natl. Acad. Sci. USA 100, 11666–11671 (2003).

    Article  Google Scholar 

  15. Aguzzi, A. Proc. Natl. Acad. Sci. USA 105, 11–12 (2008).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Aguzzi, A. Staining, straining and restraining prions. Nat Neurosci 11, 1239–1240 (2008).

Download citation

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing