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Staining, straining and restraining prions

A recent paper reported the in vitro generation of new prion strains, supporting the idea that 'strain-ness' is encoded in the protein structure itself. This lays the groundwork for a reinvigorated study of prion structure–pathology relationships.

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Figure 1: The PMCA process.

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Aguzzi, A. Staining, straining and restraining prions. Nat Neurosci 11, 1239–1240 (2008). https://doi.org/10.1038/nn1108-1239

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