Although many drug-induced neural changes are known, progress has been slow in identifying the ones that actually mediate addiction. Identifying changes that are specific to particular elements of the transition from initial to habitual to relapsing drug use may be a fruitful strategy for pinpointing which forms of drug-induced plasticity are critical for addiction.
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Kalivas, P. How do we determine which drug-induced neuroplastic changes are important?. Nat Neurosci 8, 1440–1441 (2005). https://doi.org/10.1038/nn1105-1440
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DOI: https://doi.org/10.1038/nn1105-1440
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