Cerebellin 1 is abundant in the cerebellum, but its function remains a mystery. Hirai et al. now show that this gene is required to maintain parallel fiber-Purkinje cell synapses, via the orphan glutamate receptor subunit Grid2. These findings provide further evidence that there is a molecular pathway devoted to maintenance of synapses.
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References
Zoghbi, H.Y. Science 302, 826–830 (2003).
Chklovskii, D.B., Mel, B.W. & Svoboda, K. Nature 431, 782–788 (2004).
Hua, J.Y. & Smith, S.J. Nat. Neurosci. 7, 327–332 (2004).
Hirai, H. et al. Nat. Neurosci. 8, 1534–1541 (2005).
Slemmon, J.R., Danho, W., Hempstead, J.L. & Morgan, J.I. Proc. Natl. Acad. Sci. USA 82, 7145–7148 (1985).
Bao, D., Pang, Z. & Morgan, J.I. J. Neurochem. 95, 618–629 (2005).
Kurihara, H. et al. J. Neurosci. 17, 9613–9623 (1997).
Takeuchi, T. et al. J. Neurosci. 25, 2146–2156 (2005).
Kashiwabuchi, N. et al. Cell 81, 245–252 (1995).
Kishore, U. et al. Trends Immunol. 25, 551–561 (2004).
Yue, Z. et al. Neuron 35, 921–933 (2002).
Selimi, F. et al. Neuron 37, 813–829 (2003).
McMahan, U.J. et al. Curr. Opin. Cell Biol. 4, 869–874 (1992).
Misgeld, T., Kummer, T.T., Lichtman, J.W. & Sanes, J.R. Proc. Natl. Acad. Sci. USA 102, 11088–11093 (2005).
Lin, W. et al. Neuron 46, 569–579 (2005).
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Selimi, F., Heintz, N. How neurons keep in touch. Nat Neurosci 8, 1417–1418 (2005). https://doi.org/10.1038/nn1105-1417
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DOI: https://doi.org/10.1038/nn1105-1417
