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Food for thought: a receptor finds its ligand

In C. elegans, social and solitary feeding behavior can be determined by a single amino acid change in a G protein–coupled receptor. A new study identifies ligands for this receptor and suggests how changes in behavior evolve at the molecular level.

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Figure 1: Differential responses of NPR-1 215F and NPR-1 215V receptors to ligand result in changes in feeding behavior.


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Potter, C., Luo, L. Food for thought: a receptor finds its ligand. Nat Neurosci 6, 1119–1120 (2003).

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