Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The long and winding road to memory consolidation

An imaging study suggests memories may depend briefly on the hippocampus, and for a prolonged period on the entorhinal cortex, before being organized fully within the neocortex.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Mean fMRI time series data from the entorhinal cortex (right hemisphere) in eight subjects from the famous faces remote memory test.


  1. 1

    McGaugh, J. L. Science 287, 248–251 (2000).

    CAS  Article  Google Scholar 

  2. 2

    Ribot, T. A. The Diseases of Memory (Appleton, New York, 1881).

    Google Scholar 

  3. 3

    Müller, G. E. & Pilzecher, A. Z. Psychol. Ergnzungsband 1, 1–300 (1900).

    Google Scholar 

  4. 4

    Haist. F., Gore, J. B. & Mao, H. Nat. Neurosci. 4, 1139–1145 (2001).

    CAS  Article  Google Scholar 

  5. 5

    Scoville, W. B. & Milner, B. J. Neurol. Neurosurg. Psychiat. 20, 11–12 (1957).

    CAS  Article  Google Scholar 

  6. 6

    Nadel, L. & Moscovitch, M. Curr Opin. Neurobiol. 7, 217–227 (1997).

    CAS  Article  Google Scholar 

  7. 7

    Teng, E. & Squire, L. R. Nature 400, 675–677 (1999).

    CAS  Article  Google Scholar 

  8. 8

    Squire, L. R., Clark, R. E. & Knowlton, B. J. Hippocampus 11, 50–55 (2001).

    CAS  Article  Google Scholar 

  9. 9

    Nadel, L, Samsonovich, A., Ryan, L. & Moscovitch, M. Hippocampus 10, 352–368 (2000).

    CAS  Article  Google Scholar 

  10. 10

    Maguire, E. A., Henson, R. N. A., Mummery, C. J. & Frith, C. D. Neuroreport 12, 441–444 (2001).

    CAS  Article  Google Scholar 

  11. 11

    Bontempi, B., Laurent-Demir, C., Destrade, C. & Jaffard, R. Nature 400, 671–674 (1999).

    CAS  Article  Google Scholar 

  12. 12

    Frankland, P. W., O'Brien, C., Ohno, M., Kirkwood, A. & Silva, A. J. Nature 411, 309–313 (2001).

    CAS  Article  Google Scholar 

  13. 13

    Rempel-Clower, N. L., Zola, S. M., Squire, L. R. & Amaral, D. G. J. Neurosci 16, 5233–5255 (1996).

    CAS  Article  Google Scholar 

  14. 14

    Eichenbaum, H., Dudchenko, P., Wood, E., Shapiro, M. & Tanila, H. Neuron 23, 1–20 (1999).

    Article  Google Scholar 

  15. 15

    McClelland, J. L., McNaughton, B. L. & O' Reilly, R. C. Psychol. Rev. 102, 419–457 (1995).

    Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Eichenbaum, H. The long and winding road to memory consolidation. Nat Neurosci 4, 1057–1058 (2001).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing