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Selective gene expression increases behavioral sensitivity to cocaine

Nature Neuroscience volume 2, pages 855–856 (1999)Cite this article

Abstract

Addictive drugs induce a truncated form of fosB in the striatum. A new study shows that mice engineered to mimic this expression pattern are abnormally sensitive to cocaine.

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Figure 1: Heterodimers composed of a member of the Fos family and a member of the Jun family bind DNA at AP-1 regulatory sites and generally function as transcriptional activators.

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Authors and Affiliations

  1. Director of the National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, 20892-9669, Maryland, USA

    Steven E. Hyman

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  1. Steven E. Hyman
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Hyman, S. Selective gene expression increases behavioral sensitivity to cocaine . Nat Neurosci 2, 855–856 (1999). https://doi.org/10.1038/13147

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