Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia?

Abstract

Apoptosis seems to be a dignified method of cell death, dictated by an individual cell, but new evidence that astrocytes can send apoptotic signals to neighboring cells through gap junctions challenges this model and may explain slowly spreading damage to glia after an ischemic insult.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A schematic section through gap junctions connecting glial cells.

References

  1. Finkbeiner, S. Neuron 8, 1101–1108 (1992).

    Article  CAS  Google Scholar 

  2. Berridge, M. J. J.Physiol. (Lond.) 499, 291–306 (1997).

    Article  CAS  Google Scholar 

  3. Hassinger, T. D., Guthrie, P. B., Atkinson, P. B., Bennett, M. V. L. & Kater, S. B. Proc. Natl. Acad. Sci. USA 93, 13268–13273 (1996).

    Article  CAS  Google Scholar 

  4. Nedergaard, M. Science 263, 1768–1771 (1994).

    Article  CAS  Google Scholar 

  5. Pasti, L., Volterra, A., Pozzan, T. & Carmignoto, G. J. Neurosci. 17, 7817–7830 (1997).

    Article  CAS  Google Scholar 

  6. Dermietzel, R. & Spray, D. C. Trends Neurosci. 16, 186–192 (1993).

    Article  CAS  Google Scholar 

  7. Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S. & Smith, S. J. Science 247, 470–473 (1990).

    Article  CAS  Google Scholar 

  8. Araque, A., Sanzgiri, R. P., Parpura, V. & Haydon, P. G. J. Neurosci. 18, 6822–6829 (1998).

    Article  CAS  Google Scholar 

  9. Lin, H.-C. J. et al. Nature Neurosci. 1, 494– 500 (1998).

    Article  CAS  Google Scholar 

  10. Cotrina M. L. et al. J. Neurosci. 18, 2520– 2537 (1998).

    Article  CAS  Google Scholar 

  11. Ankarcrona, M. et al. Neuron 15, 961–973 (1995).

    Article  CAS  Google Scholar 

  12. Murphy, A. N., Bredesen, D. E., Cortopassi, G., Wang, E. & Fiskum, G. Proc. Natl. Acad. Sci. USA 93, 9893–9898 (1996).

    Article  CAS  Google Scholar 

  13. Leist, M., Single, B., Castoldi, A. F., Kühnle, S. & Nicotera, P. J. Exp. Med. 185, 1481–1486 (1997).

    Article  CAS  Google Scholar 

  14. Liu, X., Kim, C. N., Yang, J., Jemmerson, R. & Wang, X. Cell 86, 147– 157 (1996).

    Article  CAS  Google Scholar 

  15. Blanc, E. M., Bruce-Keller, A. J. & Mattson, M. P. J. Neurochem. 70, 958– 970 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Budd, S., Lipton, S. Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia?. Nat Neurosci 1, 431–432 (1998). https://doi.org/10.1038/2147

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2147

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing