Inbred mouse strains are classically used to search for the genes associated with behavioral traits, including emotionality. To distinguish genetic and environmental contributions to the expression of adult behavior in mice, we investigated the effects of prenatal (embryo transfer) and postnatal (cross-fostering) environments in two strains of inbred mice with profound and reliable differences in behavior1. Here we report that strain-related behavioral differences may result from environmental factors during development rather than genetic differences between the offspring.
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Bucan, M. & Abel, T. Nat. Rev. Genet. 3, 114–123 (2002).
Crabbe, J.C., Wahlsten, D. & Dudek, B.C. Science 284, 1670–1672 (1999).
Dulawa, S.C. & Geyer, M.A. Neuropharmacology 39, 2170–2179 (2000).
Paylor, R. & Crawley, J.N. Psychopharmacology 132, 169–180 (1997).
DeFries, J.C., Thomas, E.A., Hegmann, J.P. & Weir, M.W. Psychon. Sci. 8, 207–208 (1967).
Carlier, M., Roubertoux, P. & Cohen-Salmon, C. Physiol. Behav. 30, 837–844 (1983).
Rhees, B.K., Ernst, C.A., Miao, C.H. & Atchley, W.R. Genetics 153, 905–917 (1999).
Le Roy, I., Carlier, M. & Roubertoux, P.L. Behav. Brain Res. 125, 57–64 (2001).
Brown, R.E., Mathieson, W.B., Stapleton, J. & Neumann, P.E. Physiol. Behav. 67, 599–605 (1999).
Zaharia, M.D., Kulczycki, J., Shanks, N., Meaney, M.J. & Anisman, H. Psychopharmacology 128, 227–239 (1996).
Liu, D. et al. Science 277, 1659–1662 (1997).
Liu, D., Diorio, J., Day, J.C., Francis, D.D. & Meaney, M.J. Nat. Neurosci. 3, 799–806 (2000).
Francis, D., Diorio, J., Liu, D. & Meaney, M.J. Science 286, 1155–1158 (1999).
The authors thank T. Etzel for assistance with animal care, and Cure Autism Now and the National Science Foundation IBN 9876754 for support.
The authors declare no competing financial interests.
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