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TR(I)Pping towards treatment for ischemia

A study in this issue found that suppressing expression of TRPM7 in hippocampal CA1 neurons conferred resistance to ischemic cell death, preserved cell function and prevented ischemia-induced deficits in memory.

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Figure 1: The expression and activation mechanisms of TRPM channels.

References

  1. Sun, H.-S. et al. Nat. Neurosci. 12, 1300–1307 (2009).

    CAS  Article  Google Scholar 

  2. Nilius, B. & Voets, T. Pflugers Arch. 451, 1–10 (2005).

    CAS  Article  Google Scholar 

  3. Aarts, M. et al. Cell 115, 863–877 (2003).

    CAS  Article  Google Scholar 

  4. Oancea, E., Wolfe, J.T. & Clapham, D.E. Circ. Res. 98, 245–253 (2006).

    CAS  Article  Google Scholar 

  5. Reading, S.A. & Brayden, J.E. Stroke 38, 2322–2328 (2007).

    CAS  Article  Google Scholar 

  6. Gerzanich, V. et al. Nat. Med. 15, 185–191 (2009).

    CAS  Article  Google Scholar 

  7. Krapivinsky, G. et al. Neuron 52, 485–496 (2006).

    CAS  Article  Google Scholar 

  8. Jin, J. et al. Science 322, 756–760 (2008).

    CAS  Article  Google Scholar 

  9. Schmitz, C. et al. Cell 114, 191–200 (2003).

    CAS  Article  Google Scholar 

  10. McNulty, S. & Fonfria, E. Pflugers Arch. 451, 235–242 (2005).

    CAS  Article  Google Scholar 

  11. Fonfria, E. et al. J. Neurochem. 95, 715–723 (2005).

    CAS  Article  Google Scholar 

  12. Olah, M.E. et al. J. Physiol. (Lond.) 587, 965–979 (2009).

    CAS  Article  Google Scholar 

  13. Kraft, R. et al. Am. J. Physiol. Cell Physiol. 286, C129–C137 (2004).

    CAS  Article  Google Scholar 

  14. Bond, C.E. & Greenfield, S.A. Glia 55, 1348–1361 (2007).

    Article  Google Scholar 

  15. Besancon, E. et al. Trends Pharmacol. Sci. 29, 268–275 (2008).

    CAS  Article  Google Scholar 

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Rempe, D., Takano, T. & Nedergaard, M. TR(I)Pping towards treatment for ischemia. Nat Neurosci 12, 1215–1216 (2009). https://doi.org/10.1038/nn1009-1215

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