Intercellular miscommunication in polyglutamine pathogenesis

A new paper demonstrates that polyglutamine pathogenesis in spinocerebellar ataxia need not be cell autonomous. Mutant ataxin-7 expression restricted to Bergmann glia was sufficient to cause Purkinje cell degeneration and neuronal pathology.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Potential involvement of cell interactions in polyglutamine pathogenesis.

Kim Caesar

References

  1. 1

    Tobin, A.J. & Signer, E.R. Trends Cell Biol. 10, 531–536 (2000).

  2. 2

    Ross, C.A. Neuron 35, 819–822 (2002).

  3. 3

    Custer, S.K. et al. Nat. Neurosci. 9, 1302–1311 (2006).

  4. 4

    Garden, G.A. et al. J. Neurosci. 22, 4897–4905 (2002).

  5. 5

    Burright, E.N. et al. Cell 82, 937–942 (1995).

  6. 6

    Zeron, M.M. et al. Neuron 33, 849–860 (2002).

  7. 7

    Laforet, G.A. et al. J. Neurosci. 21, 9112–9123 (2001).

  8. 8

    Shin, J.Y. et al. J. Cell Biol. 171, 1001–1012 (2005).

  9. 9

    Gu, X. et al. Neuron 46, 433–444 (2005).

  10. 10

    Cepeda, C. et al. J. Neurosci. 23, 961–969 (2003).

  11. 11

    Zuccato, C. et al. Science 293, 493–498 (2001).

  12. 12

    Nucifora, F.C. Jr. et al. Science 291, 2423–2428 (2001).

  13. 13

    Gauthier, L.R. et al. Cell 118, 127–138 (2004).

  14. 14

    Boillee, S. et al. Science 312, 1389–1392 (2006).

  15. 15

    Yazawa, I. et al. Neuron 45, 847–859 (2005).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ross, C., Cleveland, D. Intercellular miscommunication in polyglutamine pathogenesis. Nat Neurosci 9, 1205–1206 (2006). https://doi.org/10.1038/nn1006-1205

Download citation

Further reading