Hooking up new synapses

Synapse formation requires adhesive interactions between pre- and postsynaptic membranes. A new study reports that netrin-G2 ligand (NGL-2) interactions with netrin-G2 induces excitatory synapses, expanding the range of known synapse-inducing signals.

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Figure 1: NGL-2 (red) is a postsynaptic membrane protein of excitatory synapses.

Kim Caesar

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Biederer, T. Hooking up new synapses. Nat Neurosci 9, 1203–1204 (2006). https://doi.org/10.1038/nn1006-1203

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