Turning by asymmetric actin

Axon guidance requires local protein synthesis at the growth cone. Two new studies show that guidance cues induce asymmetric targeting and translation of β-actin (Actb) mRNA. Such asymmetry may be the mechanism that underlies growth cone turning.

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Figure 1: A model for guidance cue–induced asymmetric transport and translation of β-actin mRNA that initiates growth cone turning.

Kim Caesar

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Ming, G. Turning by asymmetric actin. Nat Neurosci 9, 1201–1203 (2006). https://doi.org/10.1038/nn1006-1201

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