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Turning by asymmetric actin

Nature Neuroscience volume 9, pages 12011203 (2006) | Download Citation

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Axon guidance requires local protein synthesis at the growth cone. Two new studies show that guidance cues induce asymmetric targeting and translation of β-actin (Actb) mRNA. Such asymmetry may be the mechanism that underlies growth cone turning.

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Affiliations

  1. Guo-li Ming is at the Institute for Cell Engineering and in the Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, BRB731, Baltimore, Maryland 21205, USA. gming1@jhmi.edu

    • Guo-li Ming

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DOI

https://doi.org/10.1038/nn1006-1201

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