Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Synchronous versus asynchronous transmitter release: a tale of two types of inhibitory neurons

Inhibitory cortical neurons are thought to generate temporally precise signals important for information processing, but a new study shows that CCK-expressing interneurons continue to release GABA for several hundred milliseconds after bursts of action potentials.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Differences in PV and CCK cell synapses onto a dentate granule cell in the hippocampus.

Ann Thomson

References

  1. Hefft, S & Jonas, P. Nat. Neurosci. 8, 1319–1328 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Freund, T.F. Trends Neurosci. 26, 489–495 (2003).

    Article  CAS  PubMed  Google Scholar 

  3. Pawelzik, H., Hughes, D.I. & Thomson, A.M. J. Comp. Neurol. 443, 346–367 (2002).

    Article  PubMed  Google Scholar 

  4. Atluri, P.P. & Regehr, W.G. J. Neurosci. 18, 8214–8227 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lu, T. & Trussell, L.O. Neuron 26, 683–694 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Wilson, R.I. & Nicoll, R.A. Science 296, 678–682 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. Isokawa, M. & Alger, B.E. J. Physiol. published online 21 July 2005 (10.1113/jphysiol.2005.094219).

  8. Wilson, R.I. et al. Neuron 31, 453–462 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Hestrin, S. & Galarreta, M. Trends Neurosci. 28, 304–309 (2005).

    Article  CAS  PubMed  Google Scholar 

  10. Destexhe, A. et al. Nat. Rev. Neurosci. 4, 739–751 (2003).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hestrin, S., Galarreta, M. Synchronous versus asynchronous transmitter release: a tale of two types of inhibitory neurons. Nat Neurosci 8, 1283–1284 (2005). https://doi.org/10.1038/nn1005-1283

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1005-1283

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing