Synaptic currents become faster with age. A new study uses electron microscopy, physiology and modeling to show that the progressive speeding of AMPA receptor–mediated synaptic currents during development results from changes in the structure of the synapse rather than the composition of postsynaptic receptors.
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References
Cathala, L., Holderith, N.B., Nusser, Z., DiGregorio, D.A. & Cull-Candy, S.G. Nat. Neurosci. 8, 1310–1318 (2005).
Hestrin, S. Nature 357, 686–689 (1992).
Takahashi, T., Momiyama, A., Hirai, K., Hishinuma, F. & Akagi, H. Neuron 9, 1155–1161 (1992).
Monyer, H., Seeburg, P.H. & Wisden, W. Neuron 6, 799–810 (1991).
Mosbacher, J. et al. Science 266, 1059–1062 (1994).
Hamori, J. & Somogyi, J. J. Comp. Neurol. 220, 365–377 (1983).
Silver, R.A., Traynelis, S.F. & Cull-Candy, S.G. Nature 355, 163–166 (1992).
Traynelis, S.F., Silver, R.A. & Cull-Candy, S.G. Neuron 11, 279–289 (1993).
Diamond, J.S. & Jahr, C.E. J. Neurosci. 17, 4672–4687 (1997).
Wadiche, J.I. & Jahr, C.E. Neuron 32, 301–313 (2001).
Nielsen, T.A., DiGregorio, D.A. & Silver, R.A. Neuron 42, 757–771 (2004).
Barbour, B. & Hausser, M. Trends Neurosci. 20, 377–384 (1997).
Cathala, L., Brickley, S., Cull-Candy, S. & Farrant, M. J. Neurosci. 23, 6074–6085 (2003).
Konur, S. & Ghosh, A. Neuron 46, 401–405 (2005).
Segal, M. Nat. Rev. Neurosci. 6, 277–284 (2005).
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Bergles, D. Shape-shifting at a cerebellar synapse allows submillisecond signaling. Nat Neurosci 8, 1279–1281 (2005). https://doi.org/10.1038/nn1005-1279
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DOI: https://doi.org/10.1038/nn1005-1279