Shape-shifting at a cerebellar synapse allows submillisecond signaling

Synaptic currents become faster with age. A new study uses electron microscopy, physiology and modeling to show that the progressive speeding of AMPA receptor–mediated synaptic currents during development results from changes in the structure of the synapse rather than the composition of postsynaptic receptors.

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Figure 1: Developmental changes in the structure of MF-GC synapses in the cerebellum lead to shorter synaptic currents.

Bob Crimi

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Bergles, D. Shape-shifting at a cerebellar synapse allows submillisecond signaling. Nat Neurosci 8, 1279–1281 (2005). https://doi.org/10.1038/nn1005-1279

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