Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Antisense inhibition of reward learning

Nature Neuroscience volume 7, pages 1023–1024 (2004)Cite this article

Monkeys and humans work harder for immediate than for distant rewards. How are associations between reward immediacy and sensory stimuli established in the brain? A recent study suggests a crucial role for dopamine-mediated activity in the rhinal cortex.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Effects of reduced dopamine receptor function in rhinal cortex on learned associations between visual cues and reward.

Jamie Simon, Salk Institute

References

  1. Liu, Z. & Richmond, B.J. J. Neurophysiol. 83, 1677–1692 (2000).

    Article  CAS  Google Scholar 

  2. Liu, Z., Murray, E.A. & Richmond, B.J. Nat. Neurosci. 3, 1307–1315 (2000).

    Article  CAS  Google Scholar 

  3. Liu, Z. et al. Proc. Natl. Acad. Sci. U S A 101, 12336–12341 (2004).

    Article  CAS  PubMed  Google Scholar 

  4. Wise, R.A. Nat. Rev. Neurosci. 5, 483–494 (2004).

    Article  CAS  Google Scholar 

  5. Schultz, W. Neuron 36, 241–263 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Weiss, B., Davidkova, G., Zhou, L.W., Zhang, S.P. & Morabito, M. Neurochem. Int. 31, 571–580 (1997).

    Article  CAS  Google Scholar 

  7. Davidkova, G., Zhou, L.W., Morabito, M., Zhang, S.P. & Weiss, B. J. Pharmacol. Exp. Ther. 285, 1187–1196 (1998).

    CAS  Google Scholar 

  8. Weiss, B., Davidkova, G. & Zhou, L.W. Cell. Mol. Life Sci. 55, 334–358 (1999).

    Article  CAS  Google Scholar 

  9. Davis, M.E. Curr. Opin. Biotechnol. 13, 128–131 (2002).

    Article  CAS  Google Scholar 

  10. Centonze, D., Picconi, B., Gubellini, P., Bernardi, G. & Calabresi, P.D. Eur. J. Neurosci. 13, 1071–1077 (2001).

    Article  CAS  Google Scholar 

  11. Wolf, M.E., Mangiavacchi, S. & Sun, X. Ann. N. Y. Acad. Sci. 1003, 241–249 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Vision Center Laboratory,

    Gregory D Horwitz & Edward M Callaway

  2. Systems Neurobiology Laboratories at the Salk Institute for Biological Studies, La Jolla, 92037, California, USA

    Gregory D Horwitz & Edward M Callaway

Authors
  1. Gregory D Horwitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Edward M Callaway
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Horwitz, G., Callaway, E. Antisense inhibition of reward learning. Nat Neurosci 7, 1023–1024 (2004). https://doi.org/10.1038/nn1004-1023

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1004-1023

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing