Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans

An Erratum to this article was published on 01 December 2003

Abstract

The precise localization of executive functions such as response inhibition within the prefrontal cortex (PFC), although theoretically crucial, has proven to be controversial and difficult1. Functional neuroimaging has contributed importantly to this debate1,2,3,4,5,6,7, but as human cortical lesions are seldom discrete, the literature still lacks definitive neuropsychological evidence that a specific region is necessary for task performance. We overcame this limitation by using a new observer-independent method to relate the degree of damage within a specific prefrontal region to performance on a stop-signal task that is sensitive to the neurodevelopmental aspects of stopping behavior2 and to attention-deficit/hyperactivity disorder (ADHD) as well as its amelioration by methylphenidate5,8.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Voxels activated by response inhibition in neuroimaging studies, and region of interest (ROI) approach of current study.
Figure 2: Race-model estimation of SSRT10.
Figure 3: Correlations between SSRT (ms) and the volume of damage to each region of interest (SFG, IFG, MFG, ORB, MED and pars triangularis, cm3) for 18 patients.

References

  1. Duncan, J. & Owen, A.M. Trends Neurosci. 23, 475–483 (2000).

    Article  CAS  Google Scholar 

  2. Bunge, S.A., Dudukovic, N.M., Thomason, M.E., Vaidya, C.J. & Gabrieli, J.D.E. Neuron 33, 301–311 (2002).

    Article  CAS  Google Scholar 

  3. Menon, V., Adleman, N.E., White, C.D., Glover, G.H. & Reiss, A.L. Hum. Brain Mapp. 12, 131–143 (2001).

    Article  CAS  Google Scholar 

  4. Garavan, H., Ross, T.J. & Stein, E.A. Proc. Natl. Acad. Sci. USA 96, 8301–8306 (1999).

    Article  CAS  Google Scholar 

  5. Rubia, K. et al. Am. J. Psychiatry 156, 891–896 (1999).

    Article  CAS  Google Scholar 

  6. Konishi, S., Nakajima, K., Uchida, I., Sekihara, K. & Miyashita, Y. Eur. J. Neurosci. 10, 1209–1213 (1998).

    Article  CAS  Google Scholar 

  7. Konishi, S. et al. Brain 122, 981–991 (1999).

    Article  Google Scholar 

  8. Logan, G.D., Schachar, R.J. & Tannock, R. in Attention and Performance XVIII (eds. Monsell, S. & Driver, J.) 653–677 (MIT Press, Cambridge, Massachusetts, 2000).

    Google Scholar 

  9. Brett, M., Leff, A.P., Rorden, C. & Ashburner, J. Neuroimage 14, 486–500 (2001).

    Article  CAS  Google Scholar 

  10. Logan, G.D. in Inhibitory Processes in Attention, Memory and Language (eds. Dagenbach, D. & Carr, T.H.) 189–239 (Academic, San Diego, 1994).

    Google Scholar 

  11. Williams, E.J. J. Roy. Stat. Soc. (Series B) 21, 396–399 (1959).

    Google Scholar 

  12. Tzourio-Mazoyer, N. et al. Neuroimage 15, 273–289 (2002).

    Article  CAS  Google Scholar 

  13. Goldman-Rakic, P.S. Philos. Trans. R. Soc. Lond. B Biol. Sci. 351, 1445–1453 (1996).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Patients were studied through the CCNRP, Cambridge, UK with thanks to N. Antoun. The interleaved staircases variant of the stop-signal test was developed through a Stroke Association (UK) grant to S. Monsell and I. Robertson. This work was supported by a MRC studentship to A.R.A. and a Wellcome Trust Programme Grant to B.J.S. and T.W.R. within the MRC Centre for Behavioural and Clinical Neuroscience.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Trevor W. Robbins.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Aron, A., Fletcher, P., Bullmore, E. et al. Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nat Neurosci 6, 115–116 (2003). https://doi.org/10.1038/nn1003

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1003

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing