HIV-associated neurodegeneration likely involves release of signals from activated glial cells. A new study reveals that matrix metalloproteinase from HIV-1-infected macrophages or microglia cleaves the chemokine SDF-1 to generate a potent neurotoxin.
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Ransohoff, R. Snip-snip, kill-kill: truncated SDF-1 and HIV-associated neurodegeneration. Nat Neurosci 6, 1009–1011 (2003). https://doi.org/10.1038/nn1003-1009
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DOI: https://doi.org/10.1038/nn1003-1009
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