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NCS-1 Stirs Somnolent Synapses

How is synaptic facilitation mediated? New work suggests that a calcium-sensing molecule, neuronal calcium sensor-1 (NCS-1) transduces a residual calcium signal into an enhancement of transmitter release at excitatory synapses in the hippocampus.

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Figure 1: NCS proteins.

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Zucker, R. NCS-1 Stirs Somnolent Synapses. Nat Neurosci 6, 1006–1008 (2003). https://doi.org/10.1038/nn1003-1006

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