Anxiety: at the intersection of genes and experience

Abstract

Human anxiety disorders arise from a combination of genetic vulnerability and traumatic experience. Mice with a GABAA receptor mutation may provide a model for these disorders.

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Figure 1: Individual variability in response to anxiety-provoking environments.
Figure 2: Simplified neural circuit mediating fear.

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Anagnostaras, S., Craske, M. & Fanselow, M. Anxiety: at the intersection of genes and experience. Nat Neurosci 2, 780–782 (1999). https://doi.org/10.1038/12146

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