Semaphorins: repulsive guidance molecules show their attractive side

Abstract

Semaphorins are known to repel growth cones of developing axons, but a study of the grasshopper limb bud shows that they can also serve as attractive guidance cues.

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Figure 1: Domain structure of invertebrate and vertebrate semaphorins.
Figure 2: Axon guidance phenotypes induced by blocking or overexpressing semaphorins in cultured grasshopper embryonic limb buds.

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Püschel, A. Semaphorins: repulsive guidance molecules show their attractive side . Nat Neurosci 2, 777–778 (1999). https://doi.org/10.1038/12140

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