Be careful what you train for

No effective therapeutic interventions exist for severe spinal cord injury. A report in this issue shows that rats can recover substantial 'hand' function after complete lesion of the cervical dorsal corticospinal tract, if treated with a combination of specific reaching rehabilitation exercises and chondroitinase injections to enhance axonal sprouting.

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Figure 1: Model of ChABC-induced plasticity after partial spinal cord injury.

Katie Vicari

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Tetzlaff, W., Fouad, K. & Kwon, B. Be careful what you train for. Nat Neurosci 12, 1077–1079 (2009). https://doi.org/10.1038/nn0909-1077

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