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Soporific signaling: how flies sleep through the night

The mechanisms of sleep have been studied in Drosophila melanogaster, which show behaviors reminiscent of sleep in vertebrates. A new study identifies a growth factor signaling pathway involved in sleep regulation and consolidation in this model. Inhibiting this pathway causes a sleep pattern that is similar to insomnia in humans.

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Figure 1: Proposed role of extracellular signal–regulated kinase (ERK) in the regulation of sleep in Drosophila.

Kim Caesar

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Colwell, C. Soporific signaling: how flies sleep through the night. Nat Neurosci 10, 1079–1080 (2007). https://doi.org/10.1038/nn0907-1079

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