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Soporific signaling: how flies sleep through the night

The mechanisms of sleep have been studied in Drosophila melanogaster, which show behaviors reminiscent of sleep in vertebrates. A new study identifies a growth factor signaling pathway involved in sleep regulation and consolidation in this model. Inhibiting this pathway causes a sleep pattern that is similar to insomnia in humans.

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Figure 1: Proposed role of extracellular signal–regulated kinase (ERK) in the regulation of sleep in Drosophila.

Kim Caesar


  1. Foltenyi, K., Greenspan, R.J. & Newport, J.W. Nat. Neurosci. 10, 1160–1167 (2007).

    Article  CAS  Google Scholar 

  2. Saper, C.B., Scammell, T.E. & Lu, J. Nature 437, 1257–1263 (2005).

    Article  CAS  Google Scholar 

  3. Sakurai, T. Nat. Rev. Neurosci. 8, 171–181 (2007).

    Article  CAS  Google Scholar 

  4. Zeitzer, J.M., Nishino, S. & Mignot, E. Trends Pharmacol. Sci. 27, 368–374 (2006).

    Article  CAS  Google Scholar 

  5. Siegel, J.M. Nature 437, 1264–1271 (2005).

    Article  CAS  Google Scholar 

  6. Hendricks, J.C. et al. Neuron 25, 129–138 (2000).

    Article  CAS  Google Scholar 

  7. Shaw, P.J., Cirelli, C., Greenspan, R.J. & Tononi, G. Science 287, 1834–1837 (2000).

    Article  CAS  Google Scholar 

  8. Andretic, R., van Swinderen, B. & Greenspan, R.J. Curr. Biol. 15, 1165–1175 (2005).

    Article  CAS  Google Scholar 

  9. Koh, K., Evans, J.M., Hendricks, J.C. & Sehgal, A. Proc. Natl. Acad. Sci. USA 103, 13843–13847 (2006).

    Article  CAS  Google Scholar 

  10. Kramer, A. et al. Science 294, 2511–2515 (2001).

    Article  CAS  Google Scholar 

  11. Butcher, G.Q., Lee, B. & Obrietan, K. J. Neurophysiol. 90, 3854–3863 (2003).

    Article  CAS  Google Scholar 

  12. Schrader, L.A. et al. Am. J. Physiol. Cell Physiol. 290, C852–C861 (2006).

    Article  CAS  Google Scholar 

  13. Cirelli, C. et al. Nature 434, 1087–1092 (2005).

    Article  CAS  Google Scholar 

  14. Joiner, W.J., Crocker, A., White, B.H. & Sehgal, A. Nature 441, 757–760 (2006).

    Article  CAS  Google Scholar 

  15. Pitman, J.L., McGill, J.J., Keegan, K.P. & Allada, R. Nature 441, 753–756 (2006).

    Article  CAS  Google Scholar 

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Colwell, C. Soporific signaling: how flies sleep through the night. Nat Neurosci 10, 1079–1080 (2007).

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